•In humans for example, anaerobic respiration occurs in muscles that are actively contracting and the supply of oxygen is not enough.
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•If anaerobic respiration continues for a longer period, the lactate that accumulates can cause muscular cramps. The acidic lactate denatures the enzymes, which stop the muscles from contracting.
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•After anaerobic respiration, the lactate is converted in the liver to form glucose through Cori cycle, which requires oxygen, to repay the “oxygen debt”.
Glycolysis occurs but the Krebs cycle cannot take place.
In animals, the accumulation of pyruvate stimulates the enzyme that changes it straight to lactate. A certain amount of lactate is always produced during exercise.
The total amount of ATP produced is two moles per mole of glucose used and is supplied to the muscles to continue contracting.
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